Clarksdale in January

Spring and fall are perfect - March through May and October through November give you mild weather and blooming cotton fields. The Sunflower River Blues Festival in August brings crowds but also incredible music. Summer is brutal - we're talking 95 degrees with Mississippi humidity that feels like swimming through soup. Winter is surprisingly cold and gray, though you'll have the juke joints mostly to yourself. But here's what matters more than weather: come on a weekend. Red's Lounge and Ground Zero only really come alive Thursday through Saturday nights. The Delta Blues Museum is open year-round, but the town's musical soul reveals itself after dark on weekends.